Drug May Cut Hot Flashes After Breast Cancer

Maricruz Casares
Diciembre 8, 2018

This rise is due in part to the epidemic of overweight and obesity in the USA, the Centers for Disease Control and Prevention said in a weekly report.

Even with equivalent treatments in women with hormone receptor-positive, HER2-negative breast cancer, black women had significantly higher breast cancer recurrence and increased overall mortality compared to white women in a large phase III clinical trial, TAILORx, according to data presented at the 2018 San Antonio Breast Cancer Symposium, held December 4-8, News Medical says. During the same time, the rate of white women developing uterine cancer rose 9 percent.

Uterine cancer is the fourth most common cancer and the seventh most common cause of cancer death among USA women.

More specifically, their cohort study in JAMA Oncology of more than 3,000 women found a significantly increased risk for invasive breast cancer in those with the highest levels of whole-body fat (hazard ratio [HR] 1.89, 95% CI 1.21-2.95, P 0.01), percentage of whole-body fat (HR 1.79, 95% CI 1.14-2.83, P=0.03), and trunk fat mass (HR 1.88, 95% CI 1.18-2.98, P 0.01) compared with those with the lowest.

Dr. Michael Birrer, an oncologist and director of the O'Neal Comprehensive Cancer Center at the University of Alabama at Birmingham, said he was not surprised by the report. "The reason why is not entirely understood". Another is access to health care. Black people are relatively poorer, or they live in those rural areas where they don't get the appropriate amount of health care. In 2015 more than 53000 women were diagnosed with uterine cancer and this number is getting increased every year. Twenty percent of these patients, irrespective of age, were identified as having a greater than 10 percent risk of disease recurrence before 10 years. The cancer affects the lining of the uterus, or the endometrium when too much estrogen is produced. Women who do not ovulate regularly, such as those with polycystic ovary syndrome or those on hormone replacement therapy, are at greater risk. The researchers enrolled 150 women who had experienced at least 28 hot flashes per week over more than a month, and who were bothered enough by them to want medication.

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Endometrial cancer is often detected at an early stage because it frequently produces abnormal vaginal bleeding, which prompts women to see their doctors.

Other common symptoms include pelvic pain, bleeding between periods, and bleeding after menopause.

Black women with breast cancer have worse clinical outcomes even when 21-gene recurrence scores (RS) are similar, according to a study presented at the annual San Antonio Breast Cancer Symposium, held from December 4 to 8 in Texas.

"Public health awareness is important, but more research needs to be done to address all the genetic and environmental factors that contribute to the difference in prevalence between African-American women and other groups", said Birrer.

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