Ever baby born from a uterus transplanted after death

Maricruz Casares
Diciembre 7, 2018

A healthy baby girl has been born using a uterus transplanted from a dead donor, doctors say.

The patient 32 years old was born without a uterus.

He said any doubts he had about the potential importance of uterus transplants were erased after meeting the mother of the first baby born after a live donor uterus transplant.

The baby girl was born almost a year ago to a 32-year-old woman who wasn't born with a uterus, according to the report detailed in the medical journal Lancet on Tuesday. The pregnancy went smoothly and a baby girl was delivered by caesarean section at just over 35 weeks.

There have been 10 uterus transplants from deceased donors attempted in the U.S., the Czech Republic, and Turkey, but this is the first one which resulted in a live birth. The live donors need to be family members of the woman and be willing to donate, as per the current practice. Baylor has had two successful births from live donations; Cleveland Clinic is working toward deceased donations; and her own program will be performing both living and deceased donor transplants over the next year. The 10 previous attempts to achieve pregnancies using uteruses from dead donors failed or led to miscarriages.

"They should promote education and guidance so that the groups performing uterus transplantation for the first time can benefit from the experience of the pioneers".

Surgeons spent 10.5 hours plumbing in the organ by connecting veins, arteries, ligaments and vaginal canals. The mother, whose uterus was removed in the same surgical procedure, is also healthy, the study added. The uterus is removed and immunosuppressants are stopped after birth, according to the Royal College of Obstetricians and Gynaecologists.

The first childbirth following uterine transplantation from living donors occurred in Sweden in September 2013. During the transplantation, there was a period of blood loss that was ultimately managed but might be avoidable in the future, by changing how the organ is initially reconnected to the woman's circulatory system, according to the study.

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The recipient had her first menstruation 37 days after the uterus transplant, and continued to have regular cycles after that.

The report shows that uterus transplants from deceased donors are feasible and may open access for all women with uterine infertility, without the need for live donors.

As with other organ recipients, the patient in this case was put on immune suppression drugs to reduce the chances of her body rejecting the transplant.

Later the doctors fertilised her eggs with the father-to-be's sperm and freezed them.

Two months later eight fertilised eggs were implanted into the womb.

Pregnancy was confirmed 10 days after implantation, said the medical team. The only complication during pregnancy was a kidney infection, which was treated with antibiotics.

The baby girl was seven months and 20 days old, weighing 7.5kg when the researchers wrote their report.

Dr. Richard Kennedy, President of the International Federation of Fertility Societies, who was not involved in the work, commented that the organization "welcomes this announcement, which is an anticipated evolution from live donors with clear advantages and the prospect of increasing supply for women with hitherto untreatable infertility".

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